A ‘miracle’ gas that occurs naturally in air could help reduce incidence of brain damage in newborns.

Xenon is already offered as anesthetic. But doctors are now using it in an effort to protect babies starved of oxygen at birth.

Britain Medical Research Council (MRC) is funding the world’s first trial of it’s kind into benefits of xenon on at-risk infants.

Treatment being offered at three London hospitals-University College Hospital, Evelina Children’s hospital and Queen Chariotte’s – as well as Liverpool Women’s hospital.

More than 1,000 otherwise healthy infants every year are born deprived of oxygen. Those who survive risk moderate to severe conditions ranging from learning difficulties to cerebral palsy.

Numerous factors can be to blame, including the placenta- which provides the foetus with nutrients in the womb- coming apart, the umbilical cord getting wrapped around a baby’s neck and infection.

Until now, doctors have used a technique to cool the body temperature of babies by a few degrees. This is successful in lowering the risk of brain injury in about half of cases. But experts believe adding xenon treatment to cooling could double success rates.

Brain cells are extremely sensitive to oxygen deprivation and being to die rapidly. Inhaled xenon gas treatment is understood to stop areas of the brain ‘dying’ by penetrating the cells and reviving them.

The trail is led by Professor Denis Azzopardi, a pediatric specialist at London’s Imperial College. His colleague Dr. Andrew Kapetanakis, Guy’s and St. Thomas says: ‘Birth asphyxia occurs in one or two out of 1,000 deliveries in developed countries and may have lifelong implications for the children and their families. ‘We are trying to discover if new treatment can be added to cooling to improve outcomes.’

The aim to study at least 70 babies as part of 18 month trial.

Dheeraj Dubey

(S.Y.D.Pharm.)

Tags: MET Institute of Pharmacy